Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC GSK1070916 942918-07-2 200mg
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GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways
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Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | 99.9% | 100 MG
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Trifluoperazine dihydrochloride is a potent antipsychotic agent that functions by blocking central dopamine receptors. This compound also acts as a strong α1-adrenergic receptor antagonist and a NUPR1 inhibitor, demonstrating anticancer activity. Additionally, it is a calmodulin inhibitor and can inhibit P-glycoprotein. Trifluoperazine dihydrochloride is suitable for research related to schizophrenia and has been shown to be a reversible inhibitor of influenza virus morphogenesis.
- Potent antipsychotic agent
- Blocks central dopamine receptors
- Strong α1-adrenergic receptor antagonist
- NUPR1 inhibitor with anticancer activity
- Calmodulin inhibitor
- Inhibits P-glycoprotein
- Suitable for schizophrenia research
- Reversible inhibitor of influenza virus morphogenesis
- IC50 of 16 μM for cytotoxicity in HL-60 cells by MTT assay
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TARGETMOL CHEMICALS INC LEMINOPRAZOLE 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Leminoprazole is an orally available H+K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages. purity: 99%
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Medchemexpress LLC Propidium Iodide | 25535-16-4 | 99.7% | 50 MG
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Propidium Iodide (PI) is a nuclear staining agent that stains DNA. It is an analogue of ethidine bromide, which emits red fluorescence upon embedding in double-stranded DNA. Propidium Iodide cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. It is commonly used in the detection of apoptosis or necrosis, and is often used in flow cytometry analysis.
- Nuclear staining agent for DNA.
- Emits red fluorescence upon embedding in double-stranded DNA.
- Cannot pass through living cell membranes, but stains nuclei of cells with damaged membranes.
- Fluorescence wavelength of 493/617 nm, and 536/635 nm after Mosaic with DNA.
- Commonly used in detection of apoptosis or necrosis.
- Often used in flow cytometry analysis.
- Can be used in cell cycle and cell viability assays.
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ACROTEIN CHEMBIO INC
NC3899652 /S\-A-/FMOC-AMINO\-2 3-DIH-10G
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TARGETMOL CHEMICALS INC OPAVIRALINE 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Opaviraline (GW-420867X) is a potent reverse transcriptase inhibitor that inhibits Human immunodeficiency virus 1 and has the potential to treat HIV infection. purity: 100%
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TARGETMOL CHEMICALS INC PGP-4008 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin. purity: 98%
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000568494 CEFTIOFUR-SODIUM-200MG
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eMolecules EMOLECULES INC
5000491617 7-BROMOISOQUINOLINE 1G
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eMolecules EMOLECULES INC
5000489493 6-BOC-2 4-DICHLORO-5 7-DIH 10G
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Apexbio Technology LLC Bepotastine Besilate 190786-44-8 200mg
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Bepotastine Besilate (CAS number 190786-44-8) is a small molecule antagonist targeting the histamine H1 receptor By binding selectively to this receptor subtype Bepotastine attenuates histamine-induced cellular responses decreasing symptoms associated with allergic reactions In experimental settings it serves as a pharmacological tool to investigate histamine-related inflammatory pathways and receptor signaling mechanisms Its utility extends to studies of allergic responses inflammation modulation and histamine receptor pharmacodynamics in biomedical research
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TARGETMOL CHEMICALS INC ISOFRAXIDIN 25MG
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Also available in 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. 1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines TNF-(alpha) and the phosphorylation of p38 and ERK1/2. purity: 99%
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Medchemexpress LLC m-PEG9-Amine | 211859-73-3 | >97.0% | 5 G
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m-PEG9-Amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs, and also functions as a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). It facilitates the construction of compounds that either selectively degrade target proteins via the ubiquitin-proteasome system or enable targeted delivery of cytotoxic drugs.
- Functions as a PEG-based PROTAC linker
- Suitable for the synthesis of PROTACs
- Acts as a cleavable ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Supports targeted protein degradation via the ubiquitin-proteasome system
- Enables targeted delivery of cytotoxic drugs
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Medchemexpress LLC Etonogestrel | 54048-10-1 | 99.9% | 200 MG
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Etonogestrel is an active metabolite of Desogestrel, functioning as a third-generation progesterone analogue used in various oral contraceptive preparations. It also serves as a click chemistry reagent, featuring an Alkyne group that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Etonogestrel is known to decrease PHOX2B expression by binding to the progesterone nuclear receptor PR-B.
- Third-generation progesterone analogue
- Included in oral contraceptive preparations
- Click chemistry reagent with an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Decreases PHOX2B expression by binding to the progesterone nuclear receptor PR-B
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Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 1mg, CAS: 130370-60-4.
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Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
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